Jing Qi Shen Relationship to Modern Science and Possible Explanatory Models
Although “yi, qi, jing, shen” sound esoteric, modern science increasingly probes their physiological and psychological correlates. The vocabularies differ, but a body of experimental findings partially explains classical observations:
Intent and neuroregulation. Many studies indicate that subjective intent can modulate the autonomic nervous system and bodily functions. With lower-dantian intent meditation, EEG alpha power increases and synchrony improves, indicating an ordered, relaxed brain state; β-endorphin rises, yielding well-being, anti-aging effects, and immune enhancement—matching reports of a calm “qigong state.” Metabolic rate drops, oxygen consumption decreases, and breathing slows and deepens. Sympathetic tone diminishes while vagal (parasympathetic) influence predominates, lowering heart rate, stabilizing blood pressure, relaxing muscles, and smoothing mood—physiological underpinnings of “fine, continuous breath and a tranquil mind.” Strikingly, even pure imagery (e.g., imagining pumping air) can elicit measurable EMG activity in corresponding muscles, showing that intent alone activates neural pathways and alters local blood flow and function. This supports “intent leads qi”: attentional focus establishes cortical patterns that, via autonomic pathways, modulate regional vasomotor tone and organ activity. Experiments report skin temperature rises of the navel area after 20 minutes of dantian focus, with elevated warmth persisting for hours; focusing at baihui tends to raise blood pressure, while at yongquan tends to lower it. In short, the brain’s top-down control can “regulate body and breath,” echoing qigong’s active self-regulation toward dynamic balance.
The material basis of “qi.” From a modern view, qi is not a single substance but a composite signature of respiration, circulation, neural signaling, and bioelectric phenomena that together produce the felt sense of vitality. Hypotheses propose that qigong qi sensations (warmth, flow, tingling, distension) arise from autonomic arousal patterns, neural firing, and neuromodulators (e.g., dopamine). Focused attention heightens regional neural activity and perfusion, stimulating cutaneous receptors, hence warmth/pressure where “qi arrives.” Weak bioelectric currents may prefer low-impedance pathways such as fascial planes—the modern echo of meridian transmission. Instruments sometimes detect atypical infrared, acoustic, or faint electromagnetic emissions during so-called “external qi,” hinting at measurable energy fields (still under study). Skin conductance often increases baseline resistance and dampens reactivity to stimuli in the qigong state—consistent with lower sympathetic tone and a “low-activity, high-energy” mode (reduced metabolism with conserved energy), akin to CM’s “upright qi stored within.” Over the long term, immune markers improve (e.g., saliva flow and lysozyme activity), fitting the classical observation “essence well-nourished, true qi abundant.”
A modern reading of “jing.” Traditionally linked to kidney essence and reproduction/growth/repair, jing maps plausibly to material and genetic reserves and endocrine robustness. Conserving jing means supporting anabolism and repair: sufficient nutrition, deep sleep (growth hormone and tissue repair), avoidance of excessive sexual depletion, etc. Prolonged still meditation tends to reduce stress hormones (cortisol, catecholamines) and normalize gonadotropins, favoring anabolism over catabolism. Some work suggests regular meditation may raise melatonin, slow aging, and possibly influence telomerase activity. Thus jing corresponds to stored energy and repair capacity; orderly life and mental calm improve metabolic efficiency and DNA repair, yielding vigor and disease resistance—resonating with the dictum “when essence is full, desire subsides; when essence is depleted, a hundred illnesses arise.”
“Shen” and brain science. Shen denotes conscious spirit/mental function. Neuroimaging shows that long-term meditation is associated with cortical thickening (e.g., prefrontal areas) and strengthened connectivity—enhanced attention and emotion regulation, i.e., cultivated shen. EEG in experienced practitioners often shows more stable alpha/theta patterns—deep relaxation with heightened clarity. Psychometrics frequently find better memory, reaction time, and affective stability. Reports of altered time sense and nondual well-being likely involve coordinated shifts in prefrontal–limbic dynamics. When jing is ample and energy supply to the brain is steady, with balanced neuromodulators, people exhibit bright spirit and sharp insight (“shenming appears”); when reserves are low and systems dysregulate, lethargy and distraction ensue (“loss of shen”). Mind–body therapies like meditation are effective for anxiety and depression, aligning with classical “guard spirit within” and “treat disease before it arises.”
Bridging models. While modern science cannot one-to-one equate these classical terms, interdisciplinary work builds a bridge: map jing to genetic/endocrine capacity, qi to physiological energy and signaling, shen to neurocognitive function, and yi to top-down attentional control. Data suggest intent training sculpts prefrontal control over downstream physiology; qi regulation reflects optimized autonomic balance; jing sufficiency shows up in hormonal stability and immune strength; shen cultivation in resilience and neuroplasticity. Many of these shifts are interlinked—psychoneuroimmunology documents how mental states influence immunity via neuroendocrine routes, echoing jing–qi–shen unity. As holistic science advances, “yi–qi–jing–shen” will likely gain more precise biological correlates. Scientific language may never capture the whole, yet the classical insights rest on real, trainable mind–body capacities. Brought together, scientific method can guide practice, and practice can expand science—ultimately serving human flourishing. In both East and West, body–mind integration and human–heaven unity are keys to health and excellence; coordinated development of intent, qi, essence, and spirit is a core pathway to that end.

